Tal-Gan Research Group
Chemistry Department
University of Nevada, Reno
Publications
2026
Renshaw, C.P., Basnet, A., Yeh, C.R., Wang, A., Tal-Gan, Y. Mapping the Structural Determinants of Quorum Sensing Activity in Streptococcus sinensis via Mutational Analysis of its Competence Stimulating Peptide. Biochemistry, 2026, 65, 1270-1279.
https://pubs.acs.org/doi/10.1021/acs.biochem.6c00057
2025
Brennan, A.A., Renshaw, C.P., Tata, S.C., Campanella, A., Hartman, R., Carlotz, R., Downs, M., Yurtola, A., Baum, J., Rodriguez, K.M., Bertucci, M.A., Tal-Gan, Y. The Quorum Sensing-Controlled Competence Regulon Drives H2O2 Production in Streptococcus gordonii. ACS Infect. Dis., 2025, 11, 3631-3642.
https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00926
Baral, S., Roshika, R., Renshaw, C.P., Singh, A., Prabhu, A., Jain, I., Woolsey, R., Quilici, D., Tal-Gan, Y., Sumby, P. Molecular characterization of the group A Streptococcus virulence-regulatory system FasBCAX. Molecular Microbiology, 2025, 124, 521-537.
https://onlinelibrary.wiley.com/doi/full/10.1111/mmi.70029
Mehrani, M., Mull, R.W., Guo, M., Renshaw, C.P., Singh, R.J., Tal-Gan, Y. Deciphering the Regulatory Role and Molecular Interactions That Drive the Competence Regulon Quorum Sensing Circuitry in Streptococcus constellatus. Biochemistry, 2025, 64, 3104-3113.
https://doi.org/10.1021/acs.biochem.5c00195
Brennan, A.A., Tata, S.C., Renshaw, C.P., Tal-Gan, Y. Elucidating the Role of the Competence Regulon Quorum Sensing Circuitry in Streptococcus cristatus. ACS Chem. Biol., 2025, 20, 1123-1136.
https://doi.org/10.1021/acschembio.5c00180
Sreenan, B., Kafil, V., Hunt, T., Shin, S.H.R., Brennan, A.A., Thallapally, P.K., Tal-Gan, Y., Zhu, X. Luminescent ZnO-Carbon Hybrid Nanomaterials: Synthesis, Characterization, Emission Mechanism, and Applications. ACS Appl. Opt. Mater., 2025, 3, 698-711.
https://doi.org/10.1021/acsaom.4c00509
Mehrani, M., Lella, M., Graham, K.A., Borotto, N.B., Tal-Gan, Y. Development of Urea-Bridged Cyclic Dominant Negative Pneumococcus Competence-Stimulating Peptide Analogs. Org. Biomol. Chem., 2025, 23, 1359-1372.
https://pubs.rsc.org/en/content/articlelanding/2025/ob/d4ob01524j
Ghosh, U., Tal-Gan, Y. Designing Highly Potent Side-Chain Lactam-Bridged Cyclic Competence-Stimulating Peptide-Based Quorum-Sensing Modulators in Streptococcus oligofermentans. ACS Infect. Dis., 2025, 11, 197-203.
https://doi.org/10.1021/acsinfecdis.4c00773
2024
Kafil, V., Sreenan, B., Shin, S.H.R., Brennan, A.A., Brett, P.J., AuCoin, D., Thallapally, P.K., Tal-Gan, Y., Zhu, X. Highly Active Carbon-Platinum-Based Nanozymes: Synthesis, Characterization, and Immunoassay Application. ACS Appl. Nano Mater., 2024, 7, 28283-28295.
https://doi.org/10.1021/acsanm.4c05224
Guo, M., Renshaw, C. P., Mull, R. W., Tal-Gan, Y. Noncanonical Streptococcus sanguinis ComCDE circuitry integrates environmental cues in transformation outcome decision. Cell Chem. Biol., 2024, 31, 298-311.e6.
https://doi.org/10.1016/j.chembiol.2023.09.007
2023
Milly, T. A., Renshaw, C. P., Tal-Gan, Y. Developing Multi-Species Quorum Sensing Modulators Based on the Streptococcus mitis Competence-Stimulating Peptide. J. Biol. Chem., 2023, 299, 105448.
https://doi.org/10.1016/j.jbc.2023.105448
Proutière, A., Merle D. L., Garcia-Lopez, M., Léger, C., Voegele, A., Chenal, A., Harrington, A., Tal-Gan, Y., Cokelaer, T., Trieu-Cuot, P., Dramsi, S. Gallocin A, an Atypical Two-Peptide Bacteriocin with Intramolecular Disulfide Bonds Required for Activity. Microbiol. Spectr., 2023, 11, e05085-22.
https://doi.org/10.1128/spectrum.05085-22
McBrayer, D. N., Ghosh, U., Lella, M., Cameron, C. D., Tal-Gan, Y. Peptoid-Peptide Hybrid Analogs of the Enterococcus faecalis Fsr Auto-Inducing Peptide (AIP) Reveal Crucial Structure-Activity Relationships. ChemBioChem, 2023, 24, e202200527.
https://doi.org/10.1002/cbic.202200527
Milly, T. A., Tal-Gan, Y. Targeting Peptide-Based Quorum Sensing Systems for the Treatment of Gram-Positive Bacterial Infections. Pept. Sci., 2023, 115, e24298.
https://doi.org/10.1002/pep2.24298
2022
Brennan, A. A., Harrington, A., Guo, M., Renshaw, C. P., Tillett, R. L., Miura, P., Tal-Gan, Y. Investigating the Streptococcus sinensis competence regulon through a combination of transcriptome analysis and phenotypic evaluation. Microbiology, 2022, 168, 001256
https://doi.org/10.1099/mic.0.001256
Brennan, A. A., Mehrani, M., Tal-Gan, Y. Modulating Streptococcal Phenotypes using Signal Peptide Analogs. Open Biol., 2022, 12, 220143.
https://doi.org/10.1098/rsob.220143
Oh, W.H., Lella, M., Kuo, S. H., Tal-Gan, Y., Lau, G.W. Pharmacological Evaluation of Synthetic Dominant-Negative Peptides Derived from the Competence Stimulating Peptide of Streptococcus pneumonia. ACS Pharmacol. Transl. Sci., 2022, 5, 299-305.
https://doi.org/10.1021/acsptsci.2c00037
This article was highlighted by
-
Pharmacology & Translational Science virtual special issue
“New Drug Modalities in Medicinal Chemistry, Pharmacology, and Translational Science.”
Lella, M., Oh, W.H., Kuo, S. H., Lau, G.W., Tal-Gan, Y. Attenuating the Streptococcus pneumoniae Competence Regulon using Urea-Bridged Cyclic Dominant Negative CSP Analogs. J. Med. Chem., 2022, 65, 6826-6839.
https://doi.org/10.1021/acs.jmedchem.2c00148
Milly, T.A., Buttner, A. R., Rieth, N., Hutnick, E., Engler, E. R., Campanella, A. R., Lella, M., Bertucci, M. A., Tal-Gan, Y. Optimizing CSP1 Analogs for Modulating Quorum Sensing in Streptococcus pneumoniae with Bulky, Hydrophobic Nonproteogenic Amino Acid Substitutions. RSC Chem. Biol., 2022, 3, 301-311.
https://doi.org/10.1039/D1CB00224D
Reid, K.M., Singh, A.K., Bikash, C.R., Wei. J., Tal-Gan, Y., Vinh, Q.N., Leitner, D.M. The origin and impact of bound water around intrinsically disordered proteins. Biophys. J, 2022, 121, 540-551.
https://doi.org/10.1016/j.bpj.2022.01.011
2021
Mull, R.W., Tal-Gan, Y. Elucidating the Role and Structure-Activity Relationships of the Streptococcus oligofermentans Competence Stimulating Peptide. ACS Chemical Biology, 2021, 16, 2834–2844.
https://pubs.acs.org/doi/full/10.1021/acschembio.1c00746
Milly, T. A., Engler, E. R., Chichura, K. S., Buttner, A. R., Koirala, B., Tal-Gan, Y., Bertucci, M. A. Harnessing multiple, non-proteogenic substitutions to optimize CSP:ComD hydrophobic interactions in group1 Streptococcus pneumoniae. ChemBioChem, 2021, 22, 1940-1947.
https://doi.org/10.1002/cbic.202000876
Lella, M., Tal-Gan, Y. Strategies to Attenuate the Competence Regulon in Streptococcus pneumoniae. Pept. Sci, 2021, e24222
https://doi.org/10.1002/pep2.24222
Harrington, A., Proutière, A., Mull, R. W., du Merle, L., Dramsi, S., Tal-Gan, Y. Secretion, Maturation and Activity of a Quorum Sensing Peptide (GSP) Inducing Bacteriocins Transcription in Streptococcus gallolyticus. mBio., 2021, 12, e03189-20.
https://doi.org/10.1128/mBio.03189-20
2020
Bikash, C. R., Tal-Gan, Y. Structure Activity Relationship Study of the XIP Quorum Sensing Pheromone in Streptococcus mutans Reveal Inhibitors of the Competence Regulon. ACS Chem. Biol., 2020, 15, 2833–2841.
https://doi.org/10.1021/acschembio.0c00650
Mull, R. W., Brennan, A. A., Russ, B. R., Tal-Gan, Y. Attenuating the Selection of Vancomycin Resistance Among Enterococci Through the Development of Peptide-Based Vancomycin Antagonists. ACS Infect. Dis., 2020, 6, 2913-2925.
https://doi.org/10.1021/acsinfecdis.0c00319
McBrayer, D. N., Cameron, C. D., Tal-Gan, Y. Development and utilization of peptide-based quorum sensing modulators in Gram-positive bacteria. Org. Biomol. Chem. 2020, 18, 7273-7290.
https://doi.org/10.1039/D0OB01421D
Milly, T. A., Tal-Gan, Y. Biological Evaluation of Native Streptococcal Competence Stimulating Peptides Reveal Potential Crosstalk Between Streptococcus mitis and Streptococcus pneumoniae and a New Scaffold for the Development of S. pneumoniae Quorum Sensing Modulators. RSC Chem. Biol., 2020, 1, 60-67 (Cover).
https://doi.org/10.1039/D0CB00012D
-
This article was selected to the RSC Chemical Biology ‘Analytical Methods in Chemical Biology’ Collection (2021):
Yang, Y., Lin, J., Harrington, A., Cornilescu, G., Lau, G. W., Tal-Gan, Y. Designing Cyclic Competence Stimulating Peptide (CSP) Analogs with Pan-group Quorum-Sensing Inhibition Activity in Streptococcus pneumoniae. Proc. Natl. Acad. Sci. USA, 2020, 117, 1689-1699.
https://doi.org/10.1073/pnas.1915812117
This article was highlighted by:
-
PNAS “In this Issue”:
https://www.pnas.org/content/117/3/1237
-
UNR Nevada Today:
https://www.unr.edu/nevada-today/news/2020/peptides-research-breakthrough
-
Nevada Public Radio:
https://knpr.org/knpr/2020-02/unr-researchers-aim-stop-spread-bacteria-disrupting-communication
-
KOLO 8 News Now:
https://www.kolotv.com/content/news/UNR-Researchers--568158461.html
Koirala, B., Tal-Gan, Y. Development of Streptococcus pneumoniae Pan Group Quorum Sensing Modulators. ChemBioChem. 2020, 21, 340-345 (Cover).
https://doi.org/10.1002/cbic.201900365
2019
Harrington, A., Tal-Gan, Y. The Importance of Amide Protons in Peptide Drug Development. Future Med. Chem. 2019, 11, 2759-2763.
https://doi.org/10.4155/fmc-2019-0238
Yang, Y., Tal-Gan, Y. Exploring the Competence Stimulating Peptide (CSP) N-terminal Requirements for Effective ComD Receptor Activation in Group1 Streptococcus pneumoniae. Bioorg. Chem. 2019, 89, 102987.
https://doi.org/10.1016/j.bioorg.2019.102987
Koirala, B., Phillips, N. R., Tal-Gan, Y. Unveiling the Importance of Amide Protons in CSP:ComD Interactions in Streptococcus pneumoniae. ACS Med. Chem. Lett. 2019, 10, 880-886.
https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00038
McBrayer, D. N., Tal-Gan, Y. Deciphering bacterial signalling. Nat. Chem. 2019, 11, 398-399.
https://www.nature.com/articles/s41557-019-0265-2
McBrayer, D. N., Gantman, B. K., Tal-Gan, Y. N-methylation of Amino Acids in Gelatinase Biosynthesis-Activating Pheromone (GBAP) Identifies Key Site for Stability Enhancement with Retention of the Enterococcus faecalis Fsr Quorum Sensing Circuit Response. ACS Infect. Dis. 2019, 5, 1035-1041.
https://pubs.acs.org/doi/10.1021/acsinfecdis.9b00097
Bikash, C. R., Tal-Gan, Y. Identification of Highly Potent Competence Stimulating Peptide-Based Quorum Sensing Activators in Streptococcus mutans Through the Utilization of N-Methyl and Reverse Alanine Scanning. Bioorg. Med. Chem. Lett., 2019, 29, 811-814.
https://www.sciencedirect.com/science/article/pii/S0960894X19300320
2018
Koirala, B., Lin, J., Lau, G. W., Tal-Gan, Y. Development of a Dominant Negative Competence Stimulating Peptide (dnCSP) that Attenuates Streptococcus pneumoniae Infectivity in a Mouse Model of Acute Pneumonia. ChemBioChem, 2018, 19, 2380-2386 (VIP Paper).
https://onlinelibrary.wiley.com/doi/10.1002/cbic.201800505
McBrayer, D. N., Cameron, C. D., Gantman, B. K., Tal-Gan, Y. Rational Design of Potent Activators and Inhibitors of the Enterococcus faecalis Fsr Quorum Sensing Circuit. ACS Chem. Biol., 2018, 13, 2673-2681.
https://pubs.acs.org/doi/10.1021/acschembio.8b00610
Yang, Y., Cornilescu, G., Tal-Gan, Y. Structural Characterization of Competence Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumoniae. Biochemistry, 2018, 57, 5359-5369.
https://pubs.acs.org/doi/10.1021/acs.biochem.8b00653
Koirala, B., Hillman, R. A., Tiwold, E. K., Bertucci, M. A., Tal-Gan, Y. Defining the hydrophobic interactions that drive competence stimulating peptide (CSP)-ComD binding in Streptococcus pneumoniae. Beilstein J. Org. Chem., 2018, 14, 1769-1777.
https://www.beilstein-journals.org/bjoc/articles/14/151
Bikash, C. R., Hamry, S. R., Tal-Gan, Y. Structure−Activity Relationships (SARs) of the Competence Stimulating Peptide (CSP) in Streptococcus mutans Reveal Motifs Critical for Membrane Protease SepM Recognition and ComD Receptor Activation. ACS Infect. Dis., 2018, 4, 1385-1394.
Mull, R. W., Harrington, A., Sanchez, L. A., Tal-Gan, Y. Cyclic Peptides That Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms. Curr. Top. Med. Chem., 2018, 18, 625-644.
10.2174/1568026618666180518090705
Rubin, S. J. S., Tal-Gan, Y., Gilon, C., Qvit, N. Conversion of Protein Active Regions into Peptidomimetic Therapeutic Leads using Backbone Cyclization and Cycloscan – Do It Yourself. Curr. Top. Med. Chem., 2018, 18, 556-565.
10.2174/1568026618666180518094322
Harrington, A., Tal-Gan, Y. Identification of Streptococcus gallolyticus subsp. gallolyticus (biotype I) competence stimulating peptide pheromone. J. Bacteriol., 2018, 200, e00709-17 (Cover).
https://jb.asm.org/content/200/14/e00709-17
2017
McBrayer, D. N., Tal-Gan, Y. Recent Advances in GLP-1 Receptor Agonists for Use in Diabetes Mellitus. Drug Dev. Res., 2017, 78, 292-299.
http://onlinelibrary.wiley.com/doi/10.1002/ddr.21404/abstract
McBrayer, D. N., Gantman, B. K., Cameron, C. D., Tal-Gan, Y. An Entirely Solid Phase Peptide Synthesis-Based Strategy for Synthesis of Gelatinase Biosynthesis-Activating Pheromone (GBAP) Analogue Libraries: Investigating the Structure-Activity Relationships of the Enterococcus faecalis Quorum Sensing Signal. Org. Lett., 2017, 19, 3295-3298.
http://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b01444
Yang, Y., Koirala, B., Sanchez, L. A., Phillips, N. R., Hamry, S. R., Tal-Gan, Y. Structure-Activity Relationships of the Competence Stimulating Peptides (CSPs) in Streptococcus pneumoniae Reveal Motifs Critical for intra-group and cross-group ComD Receptor Activation. ACS Chem. Biol., 2017, 12, 1141-1151.
http://pubs.acs.org/doi/abs/10.1021/acschembio.7b00007
Vasquez, J. K., Tal-Gan, Y., Cornilescu, G., Tyler, K. A., Blackwell, H. E. Simplified AIP-II Peptidomimetics are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors. ChemBioChem, 2017, 18, 413-423
http://onlinelibrary.wiley.com/wol1/doi/10.1002/cbic.201600516/full
2016
Tal-Gan, Y., Ivancic, M., Cornilescu, G., Yang, T., Blackwell, H.E. Highly Stable, Amide-Bridged Autoinducing Peptide Analogs that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus. Angew. Chem. Int. Ed., 2016, 55, 8913-8917.
http://onlinelibrary.wiley.com/doi/10.1002/anie.201602974/full
Yang, T., Tal-Gan, Y., Paharik, A.E., Horswill, A.R., Blackwell, H.E. Structure-Function Analyses of the Autoinducing Peptide I from Staphylococcus epidermidis Reveals Motifs Critical For Potent Group-Specific, Pan-Group, and Species-Specific Modulation of AgrC Quorum Sensing Receptors and Biofilm Formation. ACS Chem. Biol., 2016, 11, 1982-1991.
http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00120
Tal-Gan, Y., Ivancic, M., Cornilescu, G., Blackwell, H.E. Characterization of Structural Elements in Native Autoinducing Peptides and Non-Native Analogues that Permit the Differential Modulation of AgrC-type Quorum Sensing Receptors in Staphylococcus aureus. Org. Biomol. Chem., 2016, 14, 113-121.
http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C5OB01735A/Abstract
2015
Kratochvil, M.J., Tal-Gan, Y., Yang, T., Blackwell, H.E., Lynn, D.M. Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. ACS Biomater. Sci. Eng., 2015, 1, 1039-1049.
http://pubs.acs.org/doi/abs/10.1021/acsbiomaterials.5b00313
This article was highlighted by:
-
ACS Editors’ Choice (Sept. 22, 2015)
-
C&EN News:
http://cen.acs.org/articles/93/web/2015/09/Polymer-Coating-Interrupts-Bacterial-Conversations.html
2014
Tal-Gan, Y., Stacy, D.M., Blackwell, H.E. N-Methyl and Peptoid Scans of an Autoinducing Peptide Reveal New Structural Features Required for Inhibition and Activation of AgrC Quorum Sensing Receptors in Staphylococcus aureus. Chem. Commun., 2014, 50, 3000-3003.
http://pubs.rsc.org/en/content/articlelanding/2014/cc/c4cc00117f/divAbstract/
Broderick, A.H., Stacy, D.M., Tal-Gan, Y., Kratochvil, M.J., Blackwell, H.E., Lynn, D.M. Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus. Adv. Healthcare Mater., 2014, 3, 97-105.
http://onlinelibrary.wiley.com/doi/10.1002/adhm.201300119/abstract
2013
Tal-Gan, Y., Ivancic, M., Cornilescu, G., Cornilescu, C.C., Blackwell, H.E. Structural Characterization of Native Autoinducing Peptides and Abiotic Analogs Reveals Key Features Essential for Activation and Inhibition of an AgrC Quorum Sensing Receptor in Staphylococcus aureus. J. Am. Chem. Soc., 2013, 135, 18436-18444.
http://pubs.acs.org/doi/abs/10.1021/ja407533e
Tal-Gan, Y., Stacy, D.M., Foegen, M.K., Koenig, D.W., Blackwell, H.E. Highly Potent Inhibitors of Quorum Sensing in Staphylococcus aureus Revealed through a Systematic Synthetic Study of the Group-III Autoinducing Peptide. J. Am. Chem. Soc., 2013, 135, 7869-7882.
http://pubs.acs.org/doi/abs/10.1021/ja3112115
This article was highlighted by:
-
C&EN News:
http://cen.acs.org/articles/91/web/2013/05/Silencing-Bacterial-Communications.html
-
SciBX, a Nature translational science publication:
http://www.nature.com/scibx/journal/v6/n21/full/scibx.2013.520.html
-
The American Society for Biochemistry and Molecular Biology (ASBMB):
-
UW-Madison News:
http://www.news.wisc.edu/21812
Hurevich, M., Ratner-Hurevich, M., Tal-Gan, Y., Shalev, D.E., Ben-Sasson, S.Z., Gilon, C. Backbone Cyclic Helix Mimetic of Chemokine (C-C Motif) Receptor 2: A Rational Approach for Inhibiting Dimerization of G Protein-Coupled Receptors. Bioorg. Med. Chem., 2013, 21, 3958-3966.
http://www.sciencedirect.com/science/article/pii/S0968089613002320
Levi, I., Eskira, Y., Eisenstein, M., Gilon, C., Hoffman, A., Tal-Gan, Y., Fanous, J., Bersudsky, Y., Belmaker, R., Agam, G., Almog, O. Inhibition of inositol monophosphatase (IMPase) at the calbindin-D28k binding site: Molecular and behavioral aspects. Eur. Neuropsychopharm., 2013, 23, 1806-1815.
http://www.sciencedirect.com/science/article/pii/S0924977X15002904
2012
Horwitz, E., Tal-Gan, Y., Temper, V., Shapiro, M., Gilon, C., Hoffman, A. Chemical trapping of vancomycin - a potential strategy for preventing selection of vancomycin-resistant Enterococci. Microb. Drug Resist., 2012, 18, 109-115.
http://online.liebertpub.com/doi/abs/10.1089/mdr.2011.0057
Tal-Gan, Y., Naveh, S., Klein, S., Moshel, O., Levitzki, A., Gilon, C. Studying Protein-Peptide Interactions Using Benzophenone Units: A Case Study of PKB/Akt and its Inhibitor PTR6154. Anal. Biochem., 2012, 421, 750-754.
http://www.sciencedirect.com/science/article/pii/S0003269711007640
Naveh, S., Tal-Gan, Y., Ling, S., Hoffman, A., Holoshitz, J., Gilon, C. Developing Potent Backbone Cyclic Peptides Bearing the Shared Epitope Sequence as Rheumatoid Arthritis Drug-Leads. Bioorg. Med. Chem. Lett., 2012, 22, 493-496.
http://www.sciencedirect.com/science/article/pii/S0960894X11015058
2011
Tal-Gan, Y., Freeman, N.S., Klein, S., Levitzki, A., Gilon, C. Metabolic Stability of Peptidomimetics: N-Methyl and Aza Heptapeptide Analogs of a PKB/Akt Inhibitor. Chem. Biol. Drug Des., 2011, 78, 887-892.
http://onlinelibrary.wiley.com/doi/10.1111/j.1747-0285.2011.01207.x/abstract
Tal-Gan, Y., Hurevich, M., Klein, S., Ben-Shimon, A., Rosenthal, D., Hazan, C., Shalev, D.E., Niv, M.Y., Levitzki, A., Gilon, C. Backbone-Cyclic Peptide Inhibitors of Protein Kinase B (PKB/Akt). J. Med. Chem., 2011, 54, 5154-5164.
http://pubs.acs.org/doi/abs/10.1021/jm2003969
Freeman,N.S., Tal-Gan, Y., Klein, S., Levitzki, A., Gilon, C. Microwave-Assisted Solid-Phase Aza-peptide Synthesis: Aza Scan of a PKB/Akt Inhibitor Using Aza-arginine and Aza-proline Precursors. J. Org. Chem., 2011, 76, 3078-3085.
http://pubs.acs.org/doi/abs/10.1021/jo102422x
-
This article was selected to the ACS Virtual Special Issue on Peptide Chemistry (2012):
http://pubs.acs.org/page/vi/2012/peptide.html
2010
Tal-Gan, Y., Freeman, N.S., Klein, S., Levitzki, A., Gilon, C. Synthesis and structure-activity relationship studies of peptidomimetic PKB/Akt inhibitors: The significance of backbone interactions. Bioorg. Med. Chem., 2010, 18, 2976-2985.
http://www.sciencedirect.com/science/article/pii/S0968089610001525
Hurevich, M., Tal-Gan, Y., Klein, S., Barda, Y., Levitzki, A., Gilon, C. Novel method for the synthesis of urea backbone cyclic peptides using new Alloc protected glycine building units. J. Pept. Sci., 2010, 16, 178-185.
http://onlinelibrary.wiley.com/doi/10.1002/psc.1218/abstract